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Semaglutide

Brief Description

Semaglutide is a GLP-1 receptor agonist used primarily for the treatment of type 2 diabetes and chronic weight management. It mimics the incretin hormone GLP-1, which enhances insulin secretion, inhibits glucagon release, and slows gastric emptying, promoting satiety and reducing food intake.

Use Case

Semaglutide is used to improve blood sugar control in adults with type 2 diabetes. It is also prescribed for chronic weight management in adults with obesity or overweight conditions, in conjunction with diet and exercise.

Reconstitution

To reconstitute Semaglutide:

  1. Use sterile water or bacteriostatic water.
  2. Add the appropriate amount of water to the vial containing the Semaglutide powder. Typically, this is 1mL of water for every 5mg of peptide.
  3. Gently swirl the vial until the powder is fully dissolved. Do not shake vigorously to avoid denaturing the peptide.
  4. Use the Calculators section on our website to create custom reconstitution and dosing plans tailored to your needs.

Dosing

The typical dosing regimen for Semaglutide varies based on the individual’s needs and response:

  • Starting Dose: 0.25 mg once weekly for the first four weeks.
  • Maintenance Dose: Increase to 0.5 mg once weekly. If additional glycemic control is needed, the dose can be increased to 1 mg once weekly.
  • Max Dose: 2.4 mg once weekly for weight management, gradually increasing to this dose over 16-20 weeks to minimize gastrointestinal side effects.

Cycles:
Semaglutide is generally used on a continuous weekly dosing schedule without specific cycles. Consistency in administration is key for achieving optimal results.

Side Effects

Common side effects of Semaglutide may include:

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Abdominal pain
  • Decreased appetite

Severe but less common side effects can include pancreatitis, gallbladder disease, and thyroid tumors. Users should monitor for signs of these conditions and consult with a healthcare provider if severe symptoms occur.

Sources of Information